James missed action with a hamstring strain, but he was sharp while playing 30 minutes against the 76ers. He hit 12-of-17 shots from the field with four rebounds and five assists.
It was the 60th win of the season for Miami, which became the first NBA team this year to reach that number. Rashard Lewis added 14 points for the Heat. Ray Allen had 11 after missing Friday's game against Charlotte with an ankle sprain.
Dwyane Wade was absent for the fourth straight game with an injured leg.
Jrue Holiday scored 18 points for Philadelphia, which had won five out of seven.