Pujols' two-run shot in the first inning staked the Angels to a quick lead and Mark Trumbo also added a two-run blast in the initial frame.
Pujols and Peter Bourjos each launched a solo shot in the sixth for Los Angeles, which evened its three-game series against the Rangers.
Tommy Hanson (1-0) picked up the win in his Angels debut, yielding three runs on six hits over six frames while walking none and striking out four.
Rangers starter Matt Harrison (0-2) was rocked for five runs on eight hits over five full innings.
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