San Antonio played with a depleted lineup -- missing Tony Parker and Kawhi Leonard with knee problems. Manu Ginobili will also be out until at least the start of the playoffs due to a strained hamstring.
Center Tim Duncan, who missed the Spurs' loss to Memphis on Monday due to a sore knee, returned and played only 14 minutes. He scored five points.
San Antonio moved 1 1/2 games in front of Oklahoma City for the No. 1 seed in the Western Conference.
Orlando, which lost its ninth straight road game, went 7-of-23 from the floor in the fourth quarter. Mo Harkless led the Magic with 18 points and nine rebounds.
San Antonio went on an 11-point run in the fourth period after the Magic had closed within six with 8:33 to play.