Ginobili suffered a strain in his right hamstring in the first quarter of the Spurs' game Friday against the Los Angeles Clippers. He then missed San Antonio's game Sunday against Miami.
Subsequent examinations indicated the strain and doctors projected a 3-4-week recovery. The NBA regular season ends April 17.
Ginobili is averaging 11.9 points, 4.6 assists and 3.4 rebounds a game this season.
The San Antonio team also said Tim Duncan and Kawhi Leonard, who both have sore left knees, will miss Monday's game against Memphis.
The Spurs, at 55-18, have locked up a playoff spot. The record leads the NBA Western Conference by 1 1/2 games over the Oklahoma City Thunder.