Deng scored 28 points overall.
Jimmy Butler provided 16 points and keyed a tough defense with five steals for Chicago, which reeled off its fourth win in five games. Nate Robinson also netted 16 for the Bulls.
Rodney Stuckey came off the bench to pump in 25 points for the Pistons, who fell for the 10th time in 14 games.
Greg Monroe added 18 points and 10 rebounds for Detroit.