Memphis took a 15-point advantage into the fourth quarter and easily held on to defeat Houston at home for the fifth straight time. The Grizzlies, one of five teams in the Western Conference to have clinched a playoff spot, had dropped two in a row.
Both Randolph and Gasol finished with 21 points with Randolph claiming 12 rebounds. Gasol continued to play despite suffering from a muscle tear in his abdomen.
Mike Conley added 15 points and 10 assists for Memphis.
Houston has lost two in a row following a three-game winning streak. Chandler Parsons and Donatas Motiejunas both had 16 points for the Rockets, who picked up a mere 15 points combined from the normally high-scoring tandem of James Harden and Jeremy Lin.