Deng grabbed seven rebounds while Carlos Boozer had 18 points and 10 rebounds for Chicago, which broke a two-game losing streak and won for only the second time in six contests.
The sixth-seeded Bulls came into the contest with a 2 1/2-game cushion for a playoff spot in the East.
Indiana got 23 points and 11 rebounds from Paul George. Roy Hibbert had 18 points and 12 boards for the Pacers, who had a three-game winning streak snapped.
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