Brent Seabrook tallied with an assist while Jimmy Hayes and Andrew Shaw also found the net for Chicago, which reeled off a third straight victory to improve to an NHL-best 24-2-3.
Ray Emery needed to make only 17 saves en route to the win.
Gabriel Landeskog and Milan Hejduk notched a goal each for the last-place Avalanche, who trail the Blackhawks by 27 points in the Western Conference.
Semyon Varlamov made 27 saves for Colorado.
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