Holiday fell down as Thaddeus Young tried to find him with an inbounds pass in the closing seconds, giving the Trail Blazers a last chance for the win.
Holiday added eight rebounds and six assists while Hawes provided 18 points and 13 rebounds for Philadelphia.
The Sixers learned before the game that center Andrew Bynum will miss the rest of season. Team officials said the oft-injured big man -- obtained in a costly trade with the Los Angeles Lakers -- would undergo surgery on both knees.
The Trail Blazers got 32 points and 14 rebounds from Aldridge while tumbling to their 13th loss in 15 road games.