Aldridge got 13 of his points in the fourth quarter and also collected 12 rebounds as the Blazers finished a three-game home stand with a 2-1 mark.
Detroit's Rodney Stuckey struck for 32 points but left the game with a cut above his right eye after colliding with Lillard.
The Pistons tumbled to their eighth straight loss with Will Bynum's 23 points their best offensive performance.
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