Djokovic has won his first 17 matches this year and has a 22-match winning streak working from last October. He still has a long way to go, however, to equal the 43-match win streak he put together to begin the 2011 campaign.
He needed just 54 minutes to dispose of Tsonga, who lost to Djokovic for the ninth straight time.
Djokovic has two championships to his credit this year, including the Australian Open -- his sixth major title.
Del Potro ousted the third-seeded Murray 6-7 (6-8), 6-3, 6-1, downing the 2012 Olympic champion for only the second time in their seven confrontations.