The Jazz scored just nine points in the second period and were unable to take advantage of 24 Oklahoma City turnovers.
Durant scored 23 points and had 10 rebounds while playing less than 30 minutes of the one-sided contest.
Russell Westbrook added 19 points, nine assist and seven rebounds for the Thunder and Kevin Martin came off the bench to score 15 points. Oklahoma City won for the sixth time in seven games and was coming off a setback against San Antonio on Monday.
Utah, loser of five out of six, was led by 20 points from Gordon Hayward.