The 7-2 Hibbert hit 10-of-15 shots from the field and collected 12 rebounds in helping the Pacers steadily pull away in the fourth quarter.
He led a 50 percent shooting performance for Indiana, which has won nine of its last 12 games.
Paul George pitched in 17 points and George Hill had 16 for the Pacers.
Ricky Rubio had 21 points, six rebounds and 10 assists to lead the Timberwolves, who were unable to back up their surprising win over San Antonio Tuesday and suffered their ninth loss in 11 outings.
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