Chalmers went 5-of-6 from 3-point range while Chris Bosh drained 11-of-15 shots from the field en route to 24 points and added three blocks for Miami, which had lost by double digits in each of two prior meetings with Indiana.
Dwyane Wade added 23 points -- spurring a strong defense with six steals -- and LeBron James chipped in with 13 points, seven assists and six boards for the Heat, who extended their team-record win streak.
The Pacers were led by David West with 24 points.
Notable deaths of 2014 [PHOTOS]
Julius Randle breaks leg during NBA debut