Woods ended 54 holes at 18-under-par 198, matching the low score of the day for the third straight round and positioning himself for his seventh title at the event.
Should he go on to register a victory, it would be Woods' 16th overall World Golf Championship title but first since 2009 at the Bridgestone Invitational.
With seven birdies Saturday, Woods has racked up 24 for the event -- a three-round personal best.
Graeme McDowell's 16th-hole eagle gave him a 3-under 69 and sole possession of second place at minus-14 at the TPC Blue Monster at Doral.
Beyonce flaunts bikini body, Blue Ivy in vacation pics
Jordana Brewster on Paul Walker: 'He was an enormous presence in my life'