The Cavaliers grabbed a three-point halftime lead, but Memphis scored the first 10 points of the second half and outscored Cleveland during the third period 32-18.
Memphis has captured 11 out of 12 and has the best record of any team not leading a division. The Grizzlies, however, began the night 6 1/2 games behind San Antonio in the Southwest Division.
Kyrie Irving scored 24 points to lead the Cavaliers. He had been listed as doubtful prior to the game due to an undisclosed illness.
Notable deaths of 2014 [PHOTOS]
Michael Sam cut from the Dallas Cowboys