Sedin's tally off an assist from twin brother Henrik with 5 minutes left in the middle frame broke a 2-2 tie and was quickly followed by a Jannik Hansen score, sending the Canucks on their way to the victory.
Chris Higgins also found the net while Cory Schneider turned aside 28-of-30 shots for the Canucks.
Jordan Nolan and Justin Williams each scored as the Kings saw their five-game winning streak come to an end.
Jonathan Quick made 19 saves in the loss.
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