Higuain's marker came on a 25-yard strike that went in off the right post.
Josh Williams and Dominic Oduro followed with scores to salt the win away for the Crew (1-0-0).
Chivas (0-1-0) fell in its first game under new Coach Jose Luis Sanchez Sola.
2014: NFL Cheerleaders [PHOTOS]
UPI Sports Results for September 19, 2014