Indiana stormed to a 74-44 halftime advantage with George totaling 27 points.
The Knicks lost their third in a row, making just 5-of-28 from 3-point range and sending the Pacers to the foul line 39 times.
David West contributed 18 points and nine rebounds for the Pacers while Lance Stephenson had 14 points.
Indiana hit 53 percent of its shots from the field, recorded nine blocks and outrebounded the Knicks by 15.
Tyson Chandler led New York with 19 points and 11 boards.