Langer will vie for his 17th Champions Tour title after finishing 36 holes at 12-under 132 at the Club at TwinEagles' Talon Course.
Chien Soon Lu (4-under 68) and Tom Pernice Jr. (69) share second place at 9-under.
Mark O'Meara held sole possession of fourth at 8-under 136 after firing a 69 Saturday.
Fred Funk (71), Jeff Freeman (70) and Gene Sauers (67) finished the day tied for sixth at 6-under.
Millions of Getty images now available for free via embed tool
Ray Liotta sues skin care company over use of likeness