Blake Griffin finished with 20 points, 11 rebounds, five assists and four steals while Chauncey Billips drained four 3-pointers en route to 19 points for Los Angeles.
Jamal Crawford came off the bench to add 13 points as the Clippers won a third straight and improved to 21-5 at home.
Chandler Parsons netted 17 points and grabbed six rebounds for the Rockets, who finished a three-game road trip with a 1-2 mark.
Jeremy Lin and James Anderson added 14 points each in the loss.
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