Anderson's output while coming off the bench made up for an off night from Rudy Gay, who was held to 11 points as the Raptors headed into the all-star break with four-game winning streak.
New York's Carmelo Anthony was held to just 12 points on 4-of-21 shooting as the Knicks fell for the third time in four games.
J.R. Smith provided 26 points and Raymond Felton netted 16 in the loss.
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