The Nuggets advanced to 22-3 at home this season, a mark that ties Oklahoma City for second best in the NBA behind San Antonio.
Denver outscored the Bulls by 21 points in the third period to break things open, hitting 58 percent from the field. Kenneth Faried added 21 points and 12 rebounds for the Nuggets while Ty Lawson had 16 points and 12 assists.
Chicago lost its second in a row and is 2-3 on a six-game road trip that ends Friday in Utah. After returning home to play San Antonio on Monday, the Bulls will go back on the road for four out of five.
Carlos Boozer led Chicago with 18 points.