Erik Karlsson and Chris Phillips also found the net in the initial frame while Chris Neil added what turned out to be the game-winner in the second period for the Senators, who improved to 6-3-1 on the season.
Craig Anderson earned the win with 20 saves for Ottawa.
Jhonas Enroth was touched for all four goals on 24 shots for Buffalo.
Jessica Simpson shares three-way kiss with friends in photo
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