Kiprusoff, who has started every game for Calgary, turned aside 19-of-20 shots to earn the victory but exited the contest after the second period following a collision with Detroit's Johan Franzen.
The team said Kiprusoff had sustained a "lower body injury" and wouldn't return.
Leland Irving took over and stopped all six shots he faced in the final frame.
Franzen scored and Jimmy Howard turned aside 19-of-23 shots for the Red Wings.
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