Hawes provided 21 points and 14 rebounds while Holiday chipped in with 13 points and 14 assists as the Sixers improved to 4-1 on an eight-game homestand.
The triumph came with a price for the Sixers, however, as forward Thaddeus Young injured his left hamstring in the second quarter and didn't return.
E'Twaun Moore led cold-shooting Orlando with 18 points as the Magic tumbled to their 10th straight loss.
Notable deaths of 2014 [PHOTOS]
UPI Sports Results for September 19, 2014