Hawes provided 21 points and 14 rebounds while Holiday chipped in with 13 points and 14 assists as the Sixers improved to 4-1 on an eight-game homestand.
The triumph came with a price for the Sixers, however, as forward Thaddeus Young injured his left hamstring in the second quarter and didn't return.
E'Twaun Moore led cold-shooting Orlando with 18 points as the Magic tumbled to their 10th straight loss.
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