Kobe Bryant scored 14 points and added 14 assists, giving him three straight games in which he had 10 or more assists.
The Lakers, who won their third in a row, had 34 assists as a team to the Hornets' 21, and they won the rebounding battle 50-37.
New Orleans was led by Eric Gordon's 25 points. Gervis Vasquez added 15 points and 15 assists for the Hornets, who have lost three of their last four games.
Beautician charged with giving client fatal silicone butt injection
Attkisson leaves CBS News, reportedly over network's 'liberal bias'