San Antonio won its sixth in a row and the Spurs improved the NBA's best home record to 19-2.
The Spurs went on a 16-3 run in the fourth quarter to open a 10-point cushion, but the Hornets closed within three on a layup by Xavier Henry with 26 seconds left. Ginobili then came through at the foul line to secure the victory.
New Orleans, which had won three of its previous four, was led by Greivis Vasquez with 15 points and 11 assists.
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