Portland emphatically ended a six-game losing streak by shooting 55 percent from the field and putting all five starters in double figures.
Aldridge scored 27 points, hitting 12-of-17 from the field. Damian Lillard added 20 and J.J. Hickson contributed 14 points and 13 rebounds.
Indiana is 1-1 on a four-game road trip that will continue with games against Utah and Denver.
Paul George led the Pacers with 22 points and David West had 21.