Indiana sped to a 31-18 lead after one quarter and George kept the Pacers in front by hitting seven of their 11 3-pointers. George scored 31 points while David West had 20 points and 11 rebounds.
The Pacers produced their 11 long-range field goals on just 19 attempts and George was 7-of-9 from beyond the arc. Indiana improved its home record to 16-3, equaling Miami for the best in the Eastern Conference.
Omer Asik led Houston with 22 points and 12 rebounds. Carlos Delfino and James Harden both had 17. Harden had reached at least 20 points in 22 consecutive games and came into this contest averaging 26 points per outing.