The Nets entered the final frame trailing 75-69, but Lopez sparked a rally that included a pair of technical fouls called on the Pacers and Brooklyn cruised down the stretch for its sixth straight victory.
Lopez also hauled down nine rebounds and Deron Williams added 22 points, nine assists and five boards for the Nets.
Joe Johnson drained a trio of 3-pointers en route to 20 points in the win.
David West fired in 27 points, while Paul George contributed 15, 12 rebounds and six steals for Indiana, which had a four-game winning streak snapped.
Gerald Green came off the bench to notch 15 points for the Pacers.