Love originally broke the third and fourth metacarpals of his right hand while doing knuckle pushups during pre-season workouts and returned to the T-Wolves' lineup in November.
But he re-fractured the hand last week in a contest against Denver, and now needs surgery to correct the problem, the team said.
The procedure will be performed by Dr. Andy Weiland, a hand specialist at the Hospital for Special Surgery in New York.
Love has averaged 18.3 points and 14.0 rebounds through 18 games in limited action this season.
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