Ginobili came off the bench to add seven rebounds and four assists, while Tiago Splitter provided a double-double of 12 points and 10 boards for San Antonio.
The Spurs, whose seven-game winning streak was snapped Thursday against the New York Knicks, got back on the winning track with the help of Tim Duncan's 16 points, eight boards and four blocks.
Spencer Hawes' 22 points were the best the 76ers could do as they wrapped up an eight-game road trip with a 2-6 mark.
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