George scored 29 points, his second-largest total of the campaign, and pulled down 14 rebounds.
The Pacers built a 13-point lead after one period, but the Wizards battled back to within two early in the second half. Indiana then began to regain a comfortable lead and owned as much as a 13-point cushion in the fourth period.
Washington has lost three straight since winning for just the fourth time this season. Jordan Crawford had 20 points off the bench for the Wizards.
George's highest scoring game of the season was a 34-point effort against Chicago on Dec. 4.