Defensive back Zach Brown also provided a pair of TDs on interception returns for the Titans (6-10), who became the first team in NFL history to return two punts and two pick-offs for scores in a game.
With those four TDs, Tennessee quarterback Jake Locker didn't have to do much, and so finished 9-of-15 through the air for 152 yards as the Titans were held to 221 total yards of offense.
Chris Johnson contributed a 2-yard touchdown run in the victory.
Chad Henne picked up 298 aerial yards on 25-of-41 efficiency with two touchdowns and three interceptions as the Jaguars (2-14) completed the worst season in franchise history.
Millions of Getty images now available for free via embed tool
Ray Liotta sues skin care company over use of likeness