Crabtree made eight grabs in all and Colin Kaepernick completed 16-of-28 passes for 276 yards and the two touchdowns for the 49ers (11-4-1), who claimed the NFC West title.
Frank Gore compiled 68 yards with a score on 20 carries as San Francisco closed out the regular season with its third win in four contests.
Arizona (5-11) got a 19-of-34, 225-yard performance from Brian Hoyer in his first career NFL start behind center. He tossed a TD pass and surrendered an interception.
Michael Floyd led the Cardinals' receiving corps with eight catches for 166 yards and a touchdown.