Los Angeles won for the sixth time in seven games, bouncing back from Wednesday's loss in Denver to move back to the .500 mark.
Los Angeles never trailed, building a 14-point halftime lead and taking a 22-point advantage into the final period.
LaMarcus Aldridge led Portland with 26 points. The Trail Blazers made only 3-of-19 attempts from 3-point range.
Portland had won six of its previous seven games.