Crawford scored 22 points, Barnes added 20, and Chris Paul supplied 14, eight assists and three steals for the Clippers, who improved to an NBA-best 22-6.
Blake Griffin added another 13 points, six assists and six rebounds as Los Angeles outscored Denver 42-22 in the second period to put the game away, extending their franchise-best winning streak.
The Clippers connected on 11 three-pointers.
Kosta Koufos provided 16 points with 10 rebounds and Jordan Hamilton added 16 points off the bench for the Nuggets, who began a three-game road trip with a loss.
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