Manning completed 30-of-43 attempts and hooked up with Demaryius Thomas for 102 yards on nine receptions for the AFC West champion Broncos (12-3).
Eric Decker contributed two TD receptions among his six catches for 65 yards and Knowshon Moreno totaled 78 yards on 22 carries as Denver kept pace with Houston for the top seed in the AFC.
Colt McCoy took over from the injured Brandon Weeden in the third quarter and finished 9-of-17 through the air for 79 yards and with a 6-yard TD pass to Greg Little for the Browns (5-10).
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