The Bobcats suffered their 14th consecutive loss and are still looking for their eighth victory, which would be one more than they won during the entire 2011-12 season.
Lee scored 23 points to go with 11 rebounds and 11 assists. It was his 11th consecutive 20-point game, a career best.
Stephen Curry added 27 points for the Warriors and Klay Thompson had 20. The Warriors hit 52 percent of their field goal attempts and went 14-of-27 from 3-point range.
Golden State has won three of four and eight out of 10.
The Bobcats went through a scoreless stretch of 5 minutes spanning the second and third quarters, allowing Golden State to open a 15-point lead.
Gerald Henderson scored 24 points to lead Charlotte, which last won a game on Nov. 24 against Washington.