Matt Schaub picked up 261 aerial yards on 23-of-31 efficiency with a touchdown pass for the Texans (12-2), who bounced back from a loss to New England last week and wrapped up their second straight AFC South crown.
Andre Johnson caught a touchdown pass among his 11 receptions for 151 yards in the Texans' victory.
Andrew Luck completed a pair of TD tosses but was limited to 186 yards on 13-of-27 efficiency for the Colts (9-5), who had won seven of their last eight coming into the contest.
2014: NFL Cheerleaders [PHOTOS]
Michael Sam cut from the Dallas Cowboys