Manning completed 17 of his 28 pass attempts and Knowshon Moreno rambled for 118 yards and a score on 22 carries for the Broncos (11-3), who won their ninth straight.
Chris Harris returned an interception 98 yards for a touchdown and Eric Decker hauled down eight passes for 133 yards with a score as Denver continued its longest winning streak since 1998.
Joe Flacco threw for 254 yards on 20-of-40 efficiency with two touchdowns and an interception for the slumping Ravens (9-5), who fell for the third straight time.
Susan Sarandon: I was stoned at almost every awards show
Megyn Kelly: Santa Claus and Jesus are both white men