Holiday netted 12 of his total in the fourth quarter as the Sixers shook off a tough challenge from the Pistons and emerged with their second win in three games.
Evan Turner turned in an all-around game with 18 points, 11 rebounds and seven assists in the victory.
Thaddeus Young also had a hot night from the floor, scoring 20 points for Philadelphia.
Rodney Stuckey helped out with 19 off the bench for Detroit.
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