Lynch's total on 11 carries gave him a career-high 1,266 yards for the season as the Seahawks (8-5) recorded the most one-sided victory in team history, setting records for points in a single game and largest shutout win.
Russell Wilson tossed a touchdown while going 7-of-13 through the air for 148 yards with an interception, helping Seattle keep pace in the race with San Francisco (9-3-1) for the NFC West title.
Arizona starter John Skelton was lifted after throwing four interceptions and losing a fumble. He was replaced by Ryan Lindley, who himself was benched last week after a poor outing.
The Cardinals (4-9) dropped their NFL-worst ninth straight game.