San Antonio won its third in a row and handed the Rockets their first loss in three games.
Parker scored 17 points and handed out seven assists. The Spurs scored the first six points of the game, led by 12 at halftime and took a 21 point cushion into the final period.
Houston lost its sixth straight road outing with James Harden scoring 29 points.
The Spurs shot 55 percent from the field and missed just one of their 13 attempts from the foul line.
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