George also hauled down nine rebounds while Roy Hibbert contributed 10 points and 11 boards for the Pacers, who took advantage of 19 Chicago turnovers in the victory.
David West provided 10 points, nine rebounds and five assists as Indiana recorded its fifth win in seven outings.
The Bulls were led by Nate Robinson with 19 points.
Luol Deng contributed 17 points and seven rebounds in Chicago's setback.
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