The Celtics played the first of two games without point guard Rajon Rondo, who was suspended for his role in a shoving match on Wednesday with Brooklyn's Kris Humphries.
Boston took advantage of Portland's cold shooting to run up a 23-point lead at halftime and went on to hand the Trail Blazers their fourth straight loss.
Portland hit only 34 percent of its shots from the field and was 3-of-15 from beyond the 3-point arc. LaMarcus Aldridge led the Trail Blazers with 23 points.
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