The pair also combined for 14 rebounds for Memphis, which broke open a close game with a 16-4 run to end the contest and won going away.
Rudy Gay chipped in with 15 points and six rebounds as the Grizzlies notched their 10th win in 11 games overall.
The Cavaliers couldn't avoid their third straight loss despite 15 points and 22 rebounds from Anderson Varejao.
Dion Waiters supplied 15 points for Cleveland.
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