Knight netted 26 points while Monroe added 20 and 10 rebounds as Detroit notched its fourth win in seven contests.
Seven Pistons reached double figures in the victory -- their first of the season over a Western Conference foe -- including Kyle Singler, who supplied 16 points, 10 rebounds and five assists.
LaMarcus Aldridge returned from a stiff back to pump in 32 points with 10 boards for the Trail Blazers.
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